ELUCIDATING THE ROLE OF THE SATB1 GENE IN BREAST CANCER CARCINOGENESIS IN THE PRESENCE OR ABSENCE OF TOCOTRIENOL-RICH FRACTION: EVIDENCE FROM A SYNGENEIC MOUSE MODEL OF BREAST CANCER

Tocotrienols are reported to possess anticancer activities. Recently we showed that the effects of tocotrienolrich fraction (TRF) may be through inhibition special AT-rich sequence-binding protein 1 (SATB1) gene in a syngeneic mouse model breast cancer (BC). The present study aims further explore role SATB1 murine BC cells. expression 4T1 cells was partially knocked down (SATB1-4T1) using short hairpin RNA (shRNA) technology and these were injected into mammary pads mice. Control groups with wild-type (WT 4T1) When tumour palpable, half mice both fed daily mg TRF received intraperitoneal injections dendritic pulsed lysate (DC+TL) once week for three weeks. incidence SATB1-4T1 reduced (p<0.05) this effect independent supplementation. However, WT-4T1, there growth only group TRF. In addition, S1004A mutant P53 genes suppressed tumours from animals cells, irrespective supplementation; which also observed WT These findings suggest work pathway.